Vol 9, Issue 440
- Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling
Histone deacetylase 3 prevents chondrocytes from producing inflammatory mediators that prevent bone development.
- Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome
Induction of LTP regulates psychiatric disease–associated signaling networks in the mouse CA1 hippocampus.
This week’s article describes how the mechanical stress response could be exploited to maintain diaphragm muscle function in patients needing ventilation support.
A switch in the SUMO isoforms conjugated to Lys65 in the oncoprotein PML-RARA is not required for its arsenic-induced degradation.
SUMO switching on an oncoprotein triggers its ubiquitylation, but not necessarily its degradation, in cells exposed to arsenic.