Editors' ChoicePhysiology

Paper of note in Science Translational Medicine

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Sci. Signal.  09 Aug 2016:
Vol. 9, Issue 440, pp. ec182
DOI: 10.1126/scisignal.aai7396


A little help for the diaphragm

BGP-15 reduces ventilation-induced diaphragm dysfunction by improving diaphragm fiber and myosin function and enhancing mitochondrial activity.

H. Salah, M. Li, N. Cacciani, S. Gastaldello, H. Ogilvie, H. Akkad, A. V. Namuduri, V. Morbidoni, K. A. Artemenko, G. Balogh, V. Martinez-Redondo, P. Jannig, Y. Hedström, B. Dworkin, J. Bergquist, J. Ruas, L. Vigh, L. Salviati, L. Larsson, The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction. Sci. Transl. Med. 8, 350ra103 (2016). [Abstract]