Editors' ChoiceMEDICINE

Paper of note in Science Translational Medicine

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Sci. Signal.  16 Aug 2016:
Vol. 9, Issue 441, pp. ec187
DOI: 10.1126/scisignal.aai7880

TRANSPLANTATION

Make way for stem cells

Combining antibodies against c-Kit with CD47 blockade depletes endogenous hematopoietic stem cells and enables bone marrow transplantation without radiation or chemotherapeutics.

A. Chhabra, A. M. Ring, K. Weiskopf, P. J. Schnorr, S. Gordon, A. C. Le, H.-S. Kwon, N. G. Ring, J. Volkmer, P. Y. Ho, S. Tseng, I. L. Weissman, J. A. Shizuru, Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy. Sci. Transl. Med. 8, 351ra105 (2016). [Abstract]