Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

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Sci. Signal.  16 Aug 2016:
Vol. 9, Issue 441, pp. ec188
DOI: 10.1126/scisignal.aai7888


A different gate design

Structure of a potassium channel reveals the mechanism of the interplay between voltage-dependent and ligand gating.

J. R. Whicher, R. MacKinnon, Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism. Science 353, 664–669 (2016). [Abstract]

G. E. S. Toombes, K. J. Swartz, Twists and turns in gating ion channels with voltage. Science 353, 646–647 (2016). [Abstract]


Circadian rhythms and sleep deprivation

Activity in different brain regions varies according to circadian rhythm and homeostatic sleep pressure.

V. Muto, M. Jaspar, C. Meyer, C. Kussé, S. L. Chellappa, C. Degueldre, E. Balteau, A. S. Bourdiec, A. Luxen, B. Middleton, S. N. Archer, C. Phillips, F. Collette, G. Vandewalle, D.-J. Dijk, P. Maquet, Local modulation of human brain responses by circadian rhythmicity and sleep debt. Science 353, 687–690 (2016). [Abstract]

C. A. Czeisler, Measuring the passage of brain time. 353, 648–649 (2016). [Abstract]