Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  23 Aug 2016:
Vol. 9, Issue 442, pp. ec195
DOI: 10.1126/scisignal.aai8295


Drug-induced regeneration

Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor of Hippo kinase MST1/2 provides a therapeutic option for tissue injury and repair.

F. Fan, Z. He, L.-L. Kong, Q. Chen, Q. Yuan, S. Zhang, J. Ye, H. Liu, X. Sun, J. Geng, L. Yuan, L. Hong, C. Xiao, W. Zhang, X. Sun, Y. Li, P. Wang, L. Huang, X. Wu, Z. Ji, Q. Wu, N.-S. Xia, N. S. Gray, L. Chen, C.-H. Yun, X. Deng, D. Zhou, Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci. Transl. Med. 8, 352ra108 (2016). [Abstract]


A kinder, gentler steroid

Corticosterone is as effective as cortisol for ACTH suppression but lacks metabolic adverse effects.

M. Nixon, S. D. Mackenzie, A. I. Taylor, N. Z. M. Homer, D. E. Livingstone, R. Mouras, R. A. Morgan, D. J. Mole, R. H. Stimson, R. M. Reynolds, A. P. D. Elfick, R. Andrew, B. R. Walker, ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy. Sci. Transl. Med. 8, 352ra109 (2016). [Abstract]