Editors' ChoiceHypoxia

Paper of note in Science

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Sci. Signal.  30 Aug 2016:
Vol. 9, Issue 443, pp. ec200
DOI: 10.1126/scisignal.aai8868

POSTTRANSLATIONAL MODIFICATIONS

How hypoxia controls the kinase Akt

The Akt protein kinase is regulated by prolyl hydroxylation.

J. Guo, A. A. Chakraborty, P. Liu, W. Gan, X. Zheng, H. Inuzuka, B. Wang, J. Zhang, L. Zhang, M. Yuan, J. Novak, J. Q. Cheng, A. Toker, S. Signoretti, Q. Zhang, J. M. Asara, W. G. Kaelin Jr., W. Wei, pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner. Science 353, 929–932 (2016). [Abstract]

M. Voulgarelis, P. N. Tsichlis, Proline hydroxylation linked to Akt activation. Science 353, 870–871 (2016). [Summary]