Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  30 Aug 2016:
Vol. 9, Issue 443, pp. ec201
DOI: 10.1126/scisignal.aai8862


Naïve T cells nudged by lipid mediators

Specialized proresolving lipid mediators reduce human T cell activation and prevent TH1 and TH17 cell differentiation from naïve T cells while promoting de novo Treg induction.

V. Chiurchiù, A. Leuti, J. Dalli, A. Jacobsson, L. Battistini, M. Maccarrone, C. N. Serhan, Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. Sci. Transl. Med. 8, 353ra111 (2016). [Abstract]


Myeloma enzyme makes way for metastasis

Myeloma-expressed thymidine phosphorylase enhances bone lesion formation by acting on osteoclasts and osteoblasts.

H. Liu, Z. Liu, J. Du, J. He, P. Lin, B. Amini, M. W. Starbuck, N. Novane, J. J. Shah, R. E. Davis, J. Hou, R. F. Gagel, J. Yang, Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma. Sci. Transl. Med. 8, 353ra113 (2016). [Abstract]