Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science and Science Immunology

Sci. Signal.  27 Sep 2016:
Vol. 9, Issue 447, pp. ec224
DOI: 10.1126/scisignal.aak9765

HOST-MICROBE INTERACTIONS

Microbes teach tolerance in the gut

Pathogenic salmonella can be tolerated in the presence of a commensal bacterium that promotes gut barrier function.

K. J. Rangan, V. A. Pedicord, Y.-C. Wang, B. Kim, Y. Lu, S. Shaham, D. Mucida, H. C. Hang, A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. Science 353, 1434–1437 (2016). [Abstract]

V. A. Pedicord, A. A. K. Lockhart, K. J. Rangan, J. W. Craig, J. Loschko, A. Rogoz, H. C. Hang, D. Mucida, Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance. Sci. Immunol. 1, eaai7732 (2016). [Abstract]

NEUROSCIENCE

How brain neurons turn down the heat

Thermal stress is detected and core body temperature is controlled by a thermosensory circuit in the brain.

K. Song, H. Wang, G. B. Kamm, J. Pohle, F. de Castro Reis, P. Heppenstall, H. Wende, J. Siemens, The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia

Science 353, 1393–1398 (2016). [Abstract]

T. Bartfai, Cool by neuronal decision. Science 353, 1363–1364 (2016). [Abstract]

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