Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  04 Oct 2016:
Vol. 9, Issue 448, pp. ec229
DOI: 10.1126/scisignal.aal0216

ATHEROSCLEROSIS

Artery-saving fat

A bioactive lipokine promotes metabolic resilience of organelles and limits the progression of atherosclerosis.

I. Çimen, B. Kocatürk, S. Koyuncu, Ö. Tufanlı, U. I. Onat, A. D. Yıldırım, O. Apaydın, Ş. Demirsoy, Z. G. Aykut, U. T. Nguyen, S. M. Watkins, G. S. Hotamışlıgil, E. Erbay, Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation. Sci. Transl. Med. 8, 358ra126 (2016). [Abstract]

BIOMATERIALS

Building better bones

A new, mechanically elastic biomaterial can be custom 3D-printed, is surgically friendly, and promotes robust bone regeneration.

A. E. Jakus, A. L. Rutz, S. W. Jordan, A. Kannan, S. M. Mitchell, C. Yun, K. D. Koube, S. C. Yoo, H. E. Whiteley, C.-P. Richter, R. D. Galiano, W. K. Hsu, S. R. Stock, E. L. Hsu, R. N. Shah, Hyperelastic “bone”: A highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial. Sci. Transl. Med. 8, 358ra127 (2016). [Abstract]

MALARIA

Bolstering the host to beat malaria

Angiopoietin-1 is dysregulated in pediatric severe malaria, and targeting it prevents vascular dysfunction and death in a mouse model of cerebral malaria.

S. J. Higgins, L. A. Purcell, K. L. Silver, V. Tran, V. Crowley, M. Hawkes, A. L. Conroy, R. O. Opoka, J. G. Hay, S. E. Quaggin, G. Thurston, W. C. Liles, K. C. Kain, Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria. Sci. Transl. Med. 8, 358ra128 (2016). [Abstract]

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