Editors' ChoiceASTHMA

Paper of note in Science Translational Medicine

Sci. Signal.  11 Oct 2016:
Vol. 9, Issue 449, pp. ec235
DOI: 10.1126/scisignal.aa11603


Advanced analysis of asthma

The development of allergic asthma requires type 2 airway inflammation as well as increased sensitivity of airway epithelial cells and smooth muscle to inflammation.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, A. D. Luster, Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci. Transl. Med. 8, 359ra132 (2016). [Abstract]