FocusVASCULAR BIOLOGY

Oxidant signaling underlies PKGIα modulation of Ca2+ sparks and BKCa in myogenically active arterioles

Sci. Signal.  11 Oct 2016:
Vol. 9, Issue 449, pp. fs15
DOI: 10.1126/scisignal.aak9385

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Abstract

Local blood flow autoregulation in response to intraluminal pressure requires small artery myogenic vasoconstriction, the extent of which is thought to be governed by a feedback process that depends on Ca2+ signaling. In this issue of Science Signaling, Khavandi et al. suggest a role for cyclic guanosine monophosphate (cGMP)–dependent protein kinase G Iα (PKGIα) activated by oxidants in a cGMP-independent manner.

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