Editors' ChoiceCancer therapy

Paper of note in Science Translational Medicine

Sci. Signal.  18 Oct 2016:
Vol. 9, Issue 450, pp. ec242
DOI: 10.1126/scisignal.aal2115

CANCER

Stiff resistance to cancer therapy

Anti-VEGF therapy enhances mechanical barriers to therapy in colorectal cancer liver metastases by increasing hyaluronan deposition.

N. N. Rahbari, D. Kedrin, J. Incio, H. Liu, W. W. Ho, H. T. Nia, C. M. Edrich, K. Jung, J. Daubriac, I. Chen, T. Heishi, J. D. Martin, Y. Huang, N. Maimon, C. Reissfelder, J. Weitz, Y. Boucher, J. W. Clark, A. J. Grodzinsky, D. G. Duda, R. K. Jain, D. Fukumura, Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci. Transl. Med. 8, 360ra135 (2016). [Abstract]

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