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A PilZ domain protein for chemotaxis adds another layer to c-di-GMP–mediated regulation of flagellar motility

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Sci. Signal.  18 Oct 2016:
Vol. 9, Issue 450, pp. fs16
DOI: 10.1126/scisignal.aai8859

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Abstract

Cyclic diguanylate monophosphate (c-di-GMP) is a ubiquitous second messenger in bacteria. In this issue of Science Signaling, Xu et al. show that c-di-GMP regulates chemotaxis by binding to the PilZ domain protein MapZ to alter the methyltransferase activity of its protein partner CheR, fleshing out the c-di-GMP signaling network of the opportunistic pathogen Pseudomonas aeruginosa.

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