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Coupling an EML4-ALK–centric interactome with RNA interference identifies sensitizers to ALK inhibitors

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Sci. Signal.  18 Oct 2016:
Vol. 9, Issue 450, pp. rs12
DOI: 10.1126/scisignal.aaf5011

Article Information

vol. 9 no. 450 rs12

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History: 
  • Received February 19, 2016
  • Accepted September 29, 2016

Author Information

  1. Guolin Zhang1,
  2. Hannah Scarborough2,
  3. Jihye Kim3,
  4. Andrii I. Rozhok2,
  5. Yian Ann Chen4,
  6. Xiaohui Zhang5,
  7. Lanxi Song1,
  8. Yun Bai1,
  9. Bin Fang6,
  10. Richard Z. Liu4,
  11. John Koomen7,
  12. Aik Choon Tan3,
  13. James Degregori2, and
  14. Eric B. Haura1,*
  1. 1Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  2. 2Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  3. 3Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  4. 4Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  5. 5Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  6. 6Proteomics Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  7. 7Department of Molecular Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  1. *Corresponding author. Email: eric.haura{at}moffitt.org

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