Vol 9, Issue 451
Fat tissue produces the secreted protease ADAMTS1, which activates a pathway that inhibits diet- or glucocorticoid-stimulated expansion of adipose tissue.
- Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema
Signaling by Gq/11 is required for optimal TGFβ activation in the lung to prevent inflammation.
- Combinatorial interaction network of transcriptomic and phenotypic responses to nitrogen and hormones in the Arabidopsis thaliana root
Multivariate analysis reveals a hormone- and nutrient-regulated network that shapes root architecture.
A secreted protease inhibits diet- and glucocorticoid-induced differentiation of adipocytes (Wong et al., in 25 October 2016 issue).
Interference with protein interactions may be the mechanism of the anti-inflammatory and antiproliferative activity of dual-function ERK5 inhibitors.
This week’s articles highlight dysregulation of a tissue repair–promoting cytokine in IBD, the generation of peptides for antigen presentation, a signaling system that promotes the exchange of DNA between mycobacteria, a feedback loop that resets a plant’s response to blue light, and the structural basis for activation of a calcium channel.