Editors' ChoiceImmunology

Papers of note in Science Translational Medicine

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Sci. Signal.  25 Oct 2016:
Vol. 9, Issue 451, pp. ec249
DOI: 10.1126/scisignal.aal2597

AUTOIMMUNITY

Costimulatory blockade curbs development of autoimmunity

Autoimmune manifestations are driven by peripheral immune dysregulation in early life and are prevented by prophylactic targeting of the CD40/CD40L pathway.

T. I. Mahmoud, J. Wang, J. L. Karnell, Q. Wang, S. Wang, B. Naiman, P. Gross, P. Z. Brohawn, C. Morehouse, J. Aoyama, C. Wasserfall, L. Carter, M. A. Atkinson, D. V. Serreze, H. Braley-Mullen, T. Mustelin, R. Kolbeck, R. Herbst, R. Ettinger, Autoimmune manifestations in aged mice arise from early-life immune dysregulation. Sci. Transl. Med. 8, 361ra137 (2016). [Abstract]

CANCER

Metastasis caught in a NET

Treatment with DNase I–coated nanoparticles prevents metastasis by targeting neutrophil extracellular traps induced by cancer cells in a mouse model.

J. Park, R. W. Wysocki, Z. Amoozgar, L. Maiorino, M. R. Fein, J. Jorns, A. F. Schott, Y. Kinugasa-Katayama, Y. Lee, N. H. Won, E. S. Nakasone, S. A. Hearn, V. Küttner, J. Qiu, A. S. Almeida, N. Perurena, K. Kessenbrock, M. S. Goldberg, M. Egeblad, Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci. Transl. Med. 8, 361ra138 (2016). [Abstract]

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