Editors' ChoiceImmunology

Papers of note in Science Immunology

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Sci. Signal.  25 Oct 2016:
Vol. 9, Issue 451, pp. ec251
DOI: 10.1126/scisignal.aal2598

INFECTIOUS DISEASES

B cells hoisted by their own petard: IFN-I

Interferon-driven inflammation in chronic viral infection blocks generation of sustained B cell responses.

B. Fallet, K. Narr, Y. I. Ertuna, M. Remy, R. Sommerstein, K. Cornille, M. Kreutzfeldt, N. Page, G. Zimmer, F. Geier, T. Straub, H. Pircher, K. Larimore, P. D. Greenberg, D. Merkler, D. D. Pinschewer, Interferon-driven deletion of antiviral B cells at the onset of chronic infection. Sci. Immunol. 1, eaah6817 (2016). [Abstract]

E. A. Moseman, T. Wu, J. C. de la Torre, P. L. Schwartzberg, D. B. McGavern, Type I interferon suppresses virus-specific B cell responses by modulating CD8+ T cell differentiation. Sci. Immunol. 1, eaah3565 (2016). [Abstract]

S. Sammicheli, M. Kuka, P. Di Lucia, N. J. de Oya, M. De Giovanni, J. Fioravanti, C. Cristofani, C. G. Maganuco, B. Fallet, L. Ganzer, L. Sironi, M. Mainetti, R. Ostuni, K. Larimore, P. D. Greenberg, J. C. de la Torre, L. G. Guidotti, M. Iannacone, Inflammatory monocytes hinder antiviral B cell responses. Sci. Immunol. 1, eaah6789 (2016). [Abstract]