Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

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Sci. Signal.  01 Nov 2016:
Vol. 9, Issue 452, pp. ec258
DOI: 10.1126/scisignal.aal2935

ALLERGY

Airway allergy alleviated by hookworm protein

A secreted hookworm protein in recombinant form acts on dendritic cells to drive the expansion and mucosal homing of regulatory T cells that protect against airway inflammation in mice, and also dampens human dendritic cell and T cell activation.

S. Navarro, D. A. Pickering, I. B. Ferreira, L. Jones, S. Ryan, S. Troy, A. Leech, P. J. Hotez, B. Zhan, T. Laha, R. Prentice, T. Sparwasser, J. Croese, C. R. Engwerda, J. W. Upham, V. Julia, P. R. Giacomin, A. Loukas, Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Sci. Transl. Med. 8, 362ra143 (2016). [Abstract]

RETINAL DISEASE

Old but deadly

Senescent cells encourage abnormal blood vessels and retinal disease.

M. Oubaha, K. Miloudi, A. Dejda, V. Guber, G. Mawambo, M.-A. Germain, G. Bourdel, N. Popovic, F. A. Rezende, R. J. Kaufman, F. A. Mallette, P. Sapieha, Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. Sci. Transl. Med. 8, 362ra144 (2016). [Abstract]

MULTIPLE SCLEROSIS

A repurposed drug for neuroinflammatory disease

The approved drug NDP-MSH ameliorates neurodegeneration in mouse models of neuroinflammatory disease.

N. Mykicki, A. M. Herrmann, N. Schwab, R. Deenen, T. Sparwasser, A. Limmer, L. Wachsmuth, L. Klotz, K. Köhrer, C. Faber, H. Wiendl, T. A. Luger, S. G. Meuth, K. Loser, Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci. Transl. Med. 8, 362ra146 (2016). [Abstract]