Obligatory role for GPER in cardiovascular aging and disease

Matthias R. Meyer; Natalie C. Fredette; Christoph Daniel; Geetanjali Sharma; Kerstin Amann; Jeffrey B. Arterburn; Matthias Barton; Eric R. Prossnitz

doi:10.1126/scisignal.aag0240

Research ArticleCardiovascular Biology

Obligatory role for GPER in cardiovascular aging and disease

Matthias R. Meyer¹,*,†,‡,
Natalie C. Fredette¹,*,§,
Christoph Daniel²,
Geetanjali Sharma¹,
Kerstin Amann²,
Jeffrey B. Arterburn³,
Matthias Barton⁴,‡,||, and
Eric R. Prossnitz¹,⁵,‡,||

¹Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
²Department of Nephropathology, Friedrich-Alexander-University of Erlangen-Nürnberg, Schlossplatz 4, 91054 Erlangen, Germany.
³Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA.
⁴Molecular Internal Medicine, University of Zürich, 8057 Zürich, Switzerland.
⁵University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87106, USA.

↵‡Corresponding author. Email: matthias.meyer{at}triemli.zuerich.ch (M.R.M.); barton{at}access.uzh.ch (M.B.); eprossnitz{at}salud.unm.edu (E.R.P.)

↵* These authors contributed equally to this work.
↵† Present address: Division of Cardiology, Department of Internal Medicine, Triemli City Hospital, 8063 Zurich, Switzerland.
↵§ Present address: Department of Physiology, University of Florida, Gainesville, FL 32611, USA.
↵|| Co–senior authors of this work.

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Sci. Signal. 01 Nov 2016:
Vol. 9, Issue 452, pp. ra105
DOI: 10.1126/scisignal.aag0240

Matthias R. Meyer

Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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For correspondence: matthias.meyer@triemli.zuerich.chbarton@access.uzh.cheprossnitz@salud.unm.edu

Natalie C. Fredette

Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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Christoph Daniel

Department of Nephropathology, Friedrich-Alexander-University of Erlangen-Nürnberg, Schlossplatz 4, 91054 Erlangen, Germany.

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Geetanjali Sharma

Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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Kerstin Amann

Department of Nephropathology, Friedrich-Alexander-University of Erlangen-Nürnberg, Schlossplatz 4, 91054 Erlangen, Germany.

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Jeffrey B. Arterburn

Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA.

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Matthias Barton

Molecular Internal Medicine, University of Zürich, 8057 Zürich, Switzerland.

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For correspondence: matthias.meyer@triemli.zuerich.chbarton@access.uzh.cheprossnitz@salud.unm.edu

Eric R. Prossnitz

Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87106, USA.

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For correspondence: matthias.meyer@triemli.zuerich.chbarton@access.uzh.cheprossnitz@salud.unm.edu

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Obligatory role for GPER in cardiovascular aging and disease

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