Editors' ChoiceImmunology

Paper of note in Science Translational Medicine

Sci. Signal.  08 Nov 2016:
Vol. 9, Issue 453, pp. ec264
DOI: 10.1126/scisignal.aal3392

AUTOIMMUNITY

TYK2’s balancing act

Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically for treating autoimmune diseases.

C. A. Dendrou, A. Cortes, L. Shipman, H. G. Evans, K. E. Attfield, L. Jostins, T. Barber, G. Kaur, S. B. Kuttikkatte, O. A. Leach, C. Desel, S. L. Faergeman, J. Cheeseman, M. J. Neville, S. Sawcer, A. Compston, A. R. Johnson, C. Everett, J. I. Bell, F. Karpe, M. Ultsch, C. Eigenbrot, G. McVean, L. Fugger, Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci. Transl. Med. 8, 363ra149 (2016). [Abstract]

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