Vol 9, Issue 454
A substrate peptide that the kinase GSK-3 converts into its own inhibitor improves symptoms and cognitive function in an Alzheimer’s disease model.
- RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network (“Rhesactome”) in the striatum
Protein interaction networks of the GTPase Rhes regulate motor control in the striatum.
A peptide that inhibits the kinase GSK-3 improves symptoms in a mouse model of Alzheimer’s disease (Licht-Murava et al., in 15 November 2016 issue).
This week’s articles highlight the involvement of a cytosolic DNA sensor in the response to radiation-induced DNA damage, a peptide that can inhibit tumor growth by causing a growth factor receptor to form amyloid aggregates, and the importance of endogenous RNA interference in maintaining cell quiescence.