Editors' ChoiceImmunology

Paper of note in Science Immunology

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Sci. Signal.  15 Nov 2016:
Vol. 9, Issue 454, pp. ec271
DOI: 10.1126/scisignal.aal3842

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Regulating Blimp-1 in TH2 cells

STAT3-mediated Blimp-1 induction in T cells antagonizes STAT5’s role in promoting cell cycle and cell survival genes.

A. C. Poholek, D. Jankovic, A. V. Villarino, F. Petermann, A. Hettinga, D. S. Shouval, S. B. Snapper, S. M. Kaech, S. R. Brooks, G. Vahedi, A. Sher, Y. Kanno, J. J. O’Shea, IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci. Immunol. 1, eaaf8612 (2016). [Abstract]