Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

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Sci. Signal.  15 Nov 2016:
Vol. 9, Issue 454, pp. ec273
DOI: 10.1126/scisignal.aal3845

AMYLOIDOGENESIS

Aggregation by design

A designed peptide drives a protein that does not usually aggregate to form amyloids.

R. Gallardo, M. Ramakers, F. De Smet, F. Claes, L. Khodaparast, L. Khodaparast, J. R. Couceiro, T. Langenberg, M. Siemons, S. Nyström, L. J. Young, R. F. Laine, L. Young, E. Radaelli, I. Benilova, M. Kumar, A. Staes, M. Desager, M. Beerens, P. Vandervoort, A. Luttun, K. Gevaert, G. Bormans, M. Dewerchin, J. Van Eldere, P. Carmeliet, G. Vande Velde, C. Verfaillie, C. F. Kaminski, B. De Strooper, P. Hammarström, K. P. R. Nilsson, L. Serpell, J. Schymkowitz, F. Rousseau, De novo design of a biologically active amyloid. Science 354, aah4949 (2016). [Abstract]

DNA DAMAGE

AIMing to block tissue damage

AIM2 detects radiation-induced DNA damage and triggers intestinal epithelial cell and bone marrow cell death.

B. Hu, C. Jin, H.-B. Li, J. Tong, X. Ouyang, N. M. Cetinbas, S. Zhu, T. Strowig, F. C. Lam, C. Zhao, J. Henao-Mejia, O. Yilmaz, K. A. Fitzgerald, S. C. Eisenbarth, E. Elinav, R. A. Flavell, The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 354, 765–768 (2016). [Abstract]

CELL CYCLE

RNAi soothes the path to quiescence

RNA interference plays a critical role during the entry into and maintenance of the quiescent state of a cell.

B. Roche, B. Arcangioli, R. A. Martienssen, RNA interference is essential for cellular quiescence. Science 354, aah5651 (2016). [Abstract]

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