Demian Riccardi, Department of Chemistry, Earlham College, and Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville; Hector A. Velazquez and Jerome Baudry, Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, and University of Tennessee/Oak Ridge National Laboratory Center for Molecular Biophysics, Oak Ridge National Laboratory; baona/iStockphoto.com
Vol 9, Issue 455
- A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia
A ligand-targeted compound may alleviate hypophosphatemia-associated metabolic deficiencies in patients with excess production of FGF-23.
Unexpected drug combinations for cancer treatment emerge from modeling signaling pathways affected by genomic mutations.
This week’s articles show that some plant photoreceptors can also detect temperature, enzymes that synthesize a plant defense metabolite assemble on demand, not all phosphorylation of tau promotes neurodegeneration, and neurons thought to be part of the parasympathetic nervous system are actually sympathetic.