Research ArticlePhysiology

Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin

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Sci. Signal.  22 Nov 2016:
Vol. 9, Issue 455, pp. ra112
DOI: 10.1126/scisignal.aaf3739

Article Information

vol. 9 no. 455 ra112

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History: 
  • Received February 1, 2016
  • Accepted November 4, 2016

Author Information

  1. Takanori Sano1,*,
  2. Kentaro Kawata2,*,
  3. Satoshi Ohno2,*,
  4. Katsuyuki Yugi2,3,
  5. Hiroaki Kakuda1,
  6. Hiroyuki Kubota4,5,
  7. Shinsuke Uda4,
  8. Masashi Fujii2,
  9. Katsuyuki Kunida2,
  10. Daisuke Hoshino2,
  11. Atsushi Hatano2,
  12. Yuki Ito1,
  13. Miharu Sato2,
  14. Yutaka Suzuki1, and
  15. Shinya Kuroda1,2,6,
  1. 1Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan.
  2. 2Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  3. 3Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Bunkyo-ku, Tokyo 113-0033, Japan.
  4. 4Division of Integrated Omics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
  5. 5PRESTO, Japan Science and Technology Agency, Higashi-ku, Fukuoka 812-8582, Japan.
  6. 6Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Bunkyo-ku, Tokyo 113-0033, Japan.
  1. Corresponding author. Email: skuroda{at}bs.s.u-tokyo.ac.jp
    • * These authors contributed equally to this work.

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