Research ArticlePharmacology

A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia

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Sci. Signal.  22 Nov 2016:
Vol. 9, Issue 455, pp. ra113
DOI: 10.1126/scisignal.aaf5034

Article Information

vol. 9 no. 455 ra113

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History: 
  • Received February 19, 2016
  • Resubmitted August 2, 2016
  • Accepted November 3, 2016

Author Information

  1. Zhousheng Xiao1,
  2. Demian Riccardi2,3,*,
  3. Hector A. Velazquez3,4,
  4. Ai L. Chin5,
  5. Charles R. Yates6,
  6. Jesse D. Carrick5,
  7. Jeremy C. Smith3,4,
  8. Jerome Baudry3,4, and
  9. L. Darryl Quarles1,
  1. 1Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38165, USA.
  2. 2Department of Chemistry, Earlham College, 801 National Road West, Richmond, IN 47374, USA.
  3. 3Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
  4. 4University of Tennessee/Oak Ridge National Laboratory Center for Molecular Biophysics, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN 37830, USA.
  5. 5Department of Chemistry, Tennessee Technological University, 55 University Drive, Cookeville, TN 38501, USA.
  6. 6Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  1. Corresponding author. Email: dquarles{at}uthsc.edu
  • * Present address: Applied Chemicals and Materials Division Material Measurement Laboratory, Thermodynamics Research Center, National Institute of Standards and Technology, 325 Broadway, MS 647.01, Boulder, CO 80305, USA.

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