Editors' ChoiceCELLULAR AND MOLECULAR PHYSIOLOGY

Papers of note in Science

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Sci. Signal.  29 Nov 2016:
Vol. 9, Issue 456, pp. ec283
DOI: 10.1126/scisignal.aal4633

CELL REPROGRAMMING

For cell reprogramming, context matters

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

L. Mosteiro, C. Pantoja, N. Alcazar, R. M. Marión, D. Chondronasiou, M. Rovira, P. J. Fernandez-Marcos, M. Muñoz-Martin, C. Blanco-Aparicio, J. Pastor, G. Gómez-López, A. De Martino, M. A. Blasco, M. Abad, M. Serrano, Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science 354, aaf4445 (2016). [Abstract]

AUTOPHAGY

Open Sesame!

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

K. Tsuboyama, I. Koyama-Honda, Y. Sakamaki, M. Koike, H. Morishita, N. Mizushima, The ATG conjugation systems are important for degradation of the inner autophagosomal membrane. Science 354, 1036–1041 (2016). [Abstract]

B. Levine, Closing the loop. Science 354, 968–969 (2016). [Abstract]

BEHAVIORAL IMMUNOLOGY

Status alters immune function in macaques

Social status alters immune regulation and response to infection in macaques.

N. Snyder-Mackler, J. Sanz, J. N. Kohn, J. F. Brinkworth, S. Morrow, A. O. Shaver, J.-C. Grenier, R. Pique-Regi, Z. P. Johnson, M. E. Wilson, L. B. Barreiro, J. Tung, Social status alters immune regulation and response to infection in macaques. Science 354, 1041–1045 (2016). [Abstract]

R. M. Sapolsky, Proinflammatory primates. Science 354, 967–968 (2016). [Abstract]