Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

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Sci. Signal.  29 Nov 2016:
Vol. 9, Issue 456, pp. ec284
DOI: 10.1126/scisignal.aal4631

DRUG DEVELOPMENT

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation

Single-domain antibodies called nanobodies block P2X7, an inflammatory ion channel, reducing skin and kidney inflammation in mice.

W. Danquah, C. Meyer-Schwesinger, B. Rissiek, C. Pinto, A. Serracant-Prat, M. Amadi, D. Iacenda, J.-H. Knop, A. Hammel, P. Bergmann, N. Schwarz, J. Assunção, W. Rotthier, F. Haag, E. Tolosa, P. Bannas, E. Boué-Grabot, T. Magnus, T. Laeremans, C. Stortelers, F. Koch-Nolte, Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. Sci. Transl. Med. 8, 366ra162 (2016). [Abstract]

GENETIC DISORDERS

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification

Tissue-specific manifestations of the congenital bone-forming syndrome FOP are mediated by multiple tissue-resident stem cell populations.

D. Dey, J. Bagarova, S. J. Hatsell, K. A. Armstrong, L. Huang, J. Ermann, A. J. Vonner, Y. Shen, A. H. Mohedas, A. Lee, E. M. W. Eekhoff, A. van Schie, M. B. Demay, C. Keller, A. J. Wagers, A. N. Economides, P. B. Yu, Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci. Transl. Med. 8, 366ra163 (2016). [Abstract]

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