Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

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Sci. Signal.  06 Dec 2016:
Vol. 9, Issue 457, pp. ec290
DOI: 10.1126/scisignal.aal5119

CANCER

Running interference

An antibody to human IL-2 phenocopies CD25 and improves IL-2–based cancer immunotherapy.

N. Arenas-Ramirez, C. Zou, S. Popp, D. Zingg, B. Brannetti, E. Wirth, T. Calzascia, J. Kovarik, L. Sommer, G. Zenke, J. Woytschak, C. H. Regnier, A. Katopodis, O. Boyman, Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2. Sci. Transl. Med. 8, 367ra166 (2016). [Abstract]

Prostate cancer hide-and-seek

A radiolabeled antibody against a secreted antigen uses Fc receptor–mediated internalization for cancer imaging and therapy.

D. L. J. Thorek, P. A. Watson, S.-G. Lee, A. T. Ku, S. Bournazos, K. Braun, K. Kim, K. Sjöström, M. G. Doran, U. Lamminmäki, E. Santos, D. Veach, M. Turkekul, E. Casey, J. S. Lewis, D. S. Abou, M. R. H. van Voss, P. T. Scardino, S.-E. Strand, M. L. Alpaugh, H. I. Scher, H. Lilja, S. M. Larson, D. Ulmert, Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis. Sci. Transl. Med. 8, 367ra167 (2016). [Abstract]

PARKINSON’S DISEASE

PAKing a punch in Parkinson’s disease

PAK4-CRTC1 signaling in dopaminergic neurons mediates neuroprotection in rodent models of Parkinson’s disease.

S.-Y. Won, M.-H. Park, S.-T. You, S.-W. Choi, H.-K. Kim, C. McLean, S.-C. Bae, S. R. Kim, B. K. Jin, K. H. Lee, E.-Y. Shin, E.-G. Kim, Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson’s disease. Sci. Transl. Med. 8, 367ra170 (2016). [Abstract]