Editors' ChoiceSynthetic Biology

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Sci. Signal.  13 Dec 2016:
Vol. 9, Issue 458, pp. ec296
DOI: 10.1126/scisignal.aam5612

SYNTHETIC BIOLOGY

Engineering cells to regulate glucose

A synthetic circuit provides effective glucose regulation by designer mammalian cells in diabetic mice.

M. Xie, H. Ye, H. Wang, G. Charpin-El Hamri, C. Lormeau, P. Saxena, J. Stelling, M. Fussenegger, β-cell–mimetic designer cells provide closed-loop glycemic control. Science 354, 1296–1301 (2016). [Abstract]