Editors' ChoiceNEURODEGENERATIVE DISEASE

Paper of note in Science Translational Medicine

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Sci. Signal.  13 Dec 2016:
Vol. 9, Issue 458, pp. ec297
DOI: 10.1126/scisignal.aam5595

PARKINSON’S DISEASE

A mitochondrial target for slowing Parkinson’s disease

Mitochondrial pyruvate carrier may be a therapeutic target in Parkinson’s disease.

A. Ghosh, T. Tyson, S. George, E. N. Hildebrandt, J. A. Steiner, Z. Madaj, E. Schulz, E. Machiela, W. G. McDonald, M. L. Escobar Galvis, J. H. Kordower, J. M. Van Raamsdonk, J. R. Colca, P. Brundin, Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease. Sci. Transl. Med. 8, 368ra174 (2016). [Abstract]

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