Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

Sci. Signal.  20 Dec 2016:
Vol. 9, Issue 459, pp. ec301
DOI: 10.1126/scisignal.aam6081

PLANT PATHOLOGY

Dueling for sugars

Bacterial pathogens try to suck the sugar out of their target host plants, which respond by enhancing their own sugar transporter activity.

K. Yamada, Y. Saijo, H. Nakagami, Y. Takano, Regulation of sugar transporter activity for antibacterial defense in Arabidopsis. Science 354, 1427–1430 (2016). [Abstract]

P. N. Dodds, E. S. Lagudah, Starving the enemy. Science 354, 1377–1378 (2016). [Abstract]

PROTEIN ENGINEERING

Engineering control of cellular proteins

Sensory domains inserted into identified allosteric sites modulate structural disorder to control proteins in cells.

O. Dagliyan, M. Tarnawski, P.-H. Chu, D. Shirvanyants, I. Schlichting, N. V. Dokholyan, K. M. Hahn, Engineering extrinsic disorder to control protein activity in living cells. Science 354, 1441–1444 (2016). [Abstract]

ANTIBIOTIC RESISTANCE

Defying the onslaught of antibiotics

A review explains that bacteria have innate and inducible capacities to develop persister cells that tolerate stress, including antibiotic exposure.

A. Harms, E. Maisonneuve, K. Gerdes, Mechanisms of bacterial persistence during stress and antibiotic exposure. Science 354, aaf4268 (2016). [Abstract]

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