Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  20 Dec 2016:
Vol. 9, Issue 459, pp. ec302
DOI: 10.1126/scisignal.aam6050

CANCER

Sneak attack on breast cancer’s defense

Inhibitors of BCL-XL, combined with inhibition of the mTOR/4E-BP axis, drive regressions of PIK3CA mutant breast tumors.

G. R. Anderson, S. E.Wardell, M. Cakir, L. Crawford, J. C. Leeds, D. P. Nussbaum, P. S. Shankar, R. S. Soderquist, E. M. Stein, J. P. Tingley, P. S. Winter, E. K. Zieser-Misenheimer, H. M. Alley, A. Yllanes, V. Haney, K. L. Blackwell, S. J. McCall, D. P. McDonnell, K. C. Wood, PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. Sci. Transl. Med. 8, 369ra175 (2016). [Abstract]

AUTOIMMUNITY

A joint effect of bacteria and genetics

Aggregatibacter actinomycetemcomitans generates citrullinated autoantigens involved in rheumatoid arthritis through its pore-forming toxin leukotoxin A.

M. F. Konig, L. Abusleme, J. Reinholdt, R. J. Palmer, R. P. Teles, K. Sampson, A. Rosen, P. A. Nigrovic, J. Sokolove, J. T. Giles, N. M. Moutsopoulos, F. Andrade, Aggregatibacter actinomycetemcomitans–induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci. Transl. Med. 8, 369ra176 (2016). [Abstract]

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