Editors' Choice

MicroRNAs
Hypoxia Prevents miRNA Processing

Nancy R. Gough
21 May 2013: ec111.
Phosphorylation of a microRNA-processing protein by the EGF receptor inhibits maturation of tumor-suppressing microRNAs. Abstract »|  

Cell Biology
mTORC1 Stimulates Glutamine Metabolism

John F. Foley
21 May 2013: ec112.
The mammalian target of rapamycin complex 1 promotes glutamine metabolism by repressing expression of the gene encoding the sirtuin SIRT4. Abstract »|  

Molecular Biology
Epigenetic Regulation by Vitamin C

Leslie K. Ferrarelli
21 May 2013: ec113.
Vitamin C is a cofactor for Tet-mediated DNA demethylation. Abstract »|  

Circadian Biology
ATAXIN Clock

L. Bryan Ray
21 May 2013: ec114.
Regulation of protein translation contributes to circadian rhythms. Abstract »|  

Cell Biology
Signal Scaffolds

L. Bryan Ray
21 May 2013: ec115.
Scaffolding proteins are active participants in the Wnt and Hippo signaling networks. Abstract »|  

Cell Biology
Nuclear Actin in Action

Stella M. Hurtley
21 May 2013: ec116.
A dynamic polymeric actin structure inside the nucleus is part of the serum response in mammalian tissue culture cells. Abstract »|  

Microbiology
Stress Inside Out

Stella M. Hurtley
21 May 2013: ec117.
Gram-negative bacteria monitor lipopolysaccharide and outer-membrane protein status to detect and respond to problems. Abstract »|  

Research Articles

Physiology
Estrogen Reduces Lipid Content in the Liver Exclusively from Membrane Receptor Signaling

Ali Pedram, Mahnaz Razandi, Fiona O’Mahony, Harry Harvey, Brian J. Harvey, and Ellis R. Levin
21 May 2013: ra36.
Membrane-localized estrogen receptor can alter metabolism without translocating to the nucleus. Editor's Summary »|   Abstract »|   Full Text »|   PDF »|   Supplementary Materials »|  

G Proteins
Eukaryotic G Protein Signaling Evolved to Require G Protein–Coupled Receptors for Activation

William Bradford, Adam Buckholz, John Morton, Collin Price, Alan M. Jones, and Daisuke Urano
21 May 2013: ra37.
As eukaryotic organisms evolved, their Gα proteins switched from being self-activating to requiring an activating receptor. Editor's Summary »|   Abstract »|   Full Text »|   PDF »|   Supplementary Materials »|  

Evolution
Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways

Jishnu Das, Tommy V. Vo, Xiaomu Wei, Joseph C. Mellor, Virginia Tong, Andrew G. Degatano, Xiujuan Wang, Lihua Wang, Nicolas A. Cordero, Nathan Kruer-Zerhusen, Akihisa Matsuyama, Jeffrey A. Pleiss, Steven M. Lipkin, Minoru Yoshida, Frederick P. Roth, and Haiyuan Yu
21 May 2013: ra38.
Comparing protein-interaction networks of two species of yeast suggests that network rewiring may enable environmental adaptation. Editor's Summary »|   Abstract »|   Full Text »|   PDF »|   Supplementary Materials »|  

Perspectives

Developmental Biology
Understanding the Determinants of Notch Interactions with Its Ligands

Jose F. de Celis
21 May 2013: pe19.
Multiple regulatory events govern Notch interactions and response to its ligands. Abstract »|   Full Text »|   PDF »|  

Reviews

Cell Biology
Sticky Signaling—Adhesion Class G Protein–Coupled Receptors Take the Stage

Tobias Langenhan, Gabriela Aust, and Jörg Hamann
21 May 2013: re3.
Emerging insight on the structural and functional versatility of Adhesion-GPCRs draws a fascinating picture of the multiple signals these molecules transmit. Gloss »|   Abstract »|   Full Text »|   PDF »|