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Editors' Choice

Leslie K. Ferrarelli
22 April 2014: ec105.
Some cancer therapies may be a double-edged sword, blocking pathways that mediate tumor growth and those mediating immune recognition. Abstract »  
Annalisa M. VanHook
22 April 2014: ec106.
An exosome-delivered and cancer cell–derived microRNA increases vascular permeability and promotes metastasis. Abstract »  
Nancy R. Gough
22 April 2014: ec107.
Cis presentation of neuropilin 1 with the vascular growth factor receptor promotes angiogenesis, whereas trans presentation inhibits angiogenesis. Abstract »  
Jason D. Berndt
22 April 2014: ec108.
CSFR1 is required for the homeostasis of microglia in the adult brain. Abstract »  
Kristen L. Mueller
22 April 2014: ec109.
A long noncoding RNA regulates dendritic cell differentiation and function. Abstract »  
Pamela J. Hines
22 April 2014: ec110.
A heterodimer stands at the ready; a homodimer responds with action. Abstract »  
Nancy R. Gough
22 April 2014: ec111.
Lipid signals mediate the response to mitochondrial stress. Abstract »  



José María González-Granado, Francisco Sánchez-Madrid, Vicente Andrés, and Annalisa M. VanHook
22 April 2014: pc11.
Lamin-A links the nuclear skeleton with the cytoskeleton to modulate signaling through immunological synapses. Abstract »   Full Text »   Podcast »  


Research Articles

José M. González-Granado, Carlos Silvestre-Roig, Vera Rocha-Perugini, Laia Trigueros-Motos, Danay Cibrián, Giulia Morlino, Marta Blanco-Berrocal, Fernando G. Osorio, José M. P. Freije, Carlos López-Otín, Francisco Sánchez-Madrid, and Vicente Andrés
22 April 2014: ra37.
Communication between the nuclear lamina protein lamin-A and the actin cytoskeleton is required for optimal T cell responses. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Andrea Z. Lai, Sean Cory, Hong Zhao, Mathieu Gigoux, Anie Monast, Marie-Christine Guiot, Sidong Huang, Ali Tofigh, Crista Thompson, Monica Naujokas, Victoria A. Marcus, Nicholas Bertos, Bita Sehat, Rushika M. Perera, Emily S. Bell, Brent D. G. Page, Patrick T. Gunning, Lorenzo E. Ferri, Michael Hallett, and Morag Park
22 April 2014: ra38.
Understanding how inhibitors rewire the Met receptor pathway points to a strategy for more effective gastric cancer treatment. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882