Partners in Crime: Ubiquitin-Mediated Degradation and Autophagy

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Sci. Signal.  14 Jun 2011:
DOI: 10.1126/scisignal.2002052


Recent focus on autophagy research has led to new insights on the involvement of ubiquitin (Ub)-mediated signaling as a selectivity factor in autophagy, which is generally considered a nonselective global degradation system. Emerging reports have demonstrated active crosstalk between the Ub-dependent proteolytic system and autophagy. This article highlights recent reports describing Ub-mediated selective autophagy regulated by the Toll-like receptor 4–induced immune response.

Full article available 21 June 2011, Vol. 4, Issue 178, pp. jc4