Focus Issue: Wnt and β-Catenin Signaling in Development and Disease

Sci. Signal.  03 Jan 2012:

DOI: 10.1126/scisignal.2002806


The Wnt pathways represent key signaling networks involved in development, both in tissue specification and in cellular migration. Wnt signaling also plays key roles in tissue homeostasis in adult animals, and aberrant Wnt signaling is associated with several forms of cancer. This issue includes a description of a proapoptotic function for Wnt signaling in melanoma, of an interplay between Wnt and bone morphogenetic proteins in tooth organogenesis, and of a noncanonical role for Wnt in neuronal guidance.

Full article available 10 January 2012, Vol. 5, Issue 206, pp. eg2