LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?

Science Signaling  10 Jan 2012:

DOI: 10.1126/scisignal.2002680


Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson’s disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn’s disease. Here, we examine how LRRK2’s role as a signaling hub in the cell could lead to diverse pathologies.

Full article available 17 January 2012, Vol. 205, Issue 207, pp. pe2