Focus Issue: Signaling Architecture from Domains to Complexes

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Sci. Signal.  22 May 2012:
DOI: 10.1126/scisignal.2003235


Science Signaling concludes a series on structural biology, which has focused on the use of structural approaches to understand signal transduction. Articles in this issue highlight the importance of the helical domain in Gα proteins, discuss how linear peptide motifs are recognized by a protein domain, and describe the assembly of macromolecular complexes upon activation of Toll-like and interleukin-1 receptors.

Full article available 29 May 2012, Vol. 5, Issue 226, pp. eg7