L-Type Calcium Channels: On the Fast Track to Nuclear Signaling

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Sci. Signal.  07 Aug 2012:
DOI: 10.1126/scisignal.2003355


Calcium signaling resulting from depolarization of neurons can trigger changes in transcription, and this response has been called excitation-transcription (E-T) coupling. In neurons, voltage-gated and ligand-gated calcium-permeable channels contribute to the increase in intracellular calcium. It appears that calcium signals mediated by specific voltage-gated calcium channels may have distinct roles in E-T coupling.

Full article available 14 August 2012, Vol. 5, Issue 237, pp. pe34