HCN1 Channels: A New Therapeutic Target for Depressive Disorders?

Sci. Signal.  25 Sep 2012:

DOI: 10.1126/scisignal.2003593


The hyperpolarization-activated cyclic nucleotide-gated channels are cation channels that are activated by hyperpolarizing potentials. These channels are concentrated in cortical and hippocampal pyramidal cell dendrites, where they play an important role in determining synaptic input integration and thus neuronal output. These channels have thus been suggested to be involved in physiological processes, such as cognition, as well as pathophysiological states, such as epilepsy. Recent evidence suggests that these channels may also be therapeutic targets for treatment of depressive disorders.

Full article available 2 October 2012, Vol. 5, Issue 244, pp. pe44