PTEN: An Intercellular Peacekeeper?

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Sci. Signal.  06 Nov 2012:
DOI: 10.1126/scisignal.2003685


It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer cell, it is expected that loss of protein function will follow. A provocative study indicates an unexpected mechanism of intercellular tumor suppression, showing that PTEN (phosphatase and tensin homolog deleted from chromosome 10), a cytosolic enzyme, can be transferred between cells in exosomes to suppress signaling and proliferation in target cells.

Full article available 13 November 2012, Vol. 5, Issue 250, pe50