Sequential Conformational Rearrangements Dictate the Dynamics of Class C GPCR Activation

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Sci. Signal.  13 Nov 2012:
DOI: 10.1126/scisignal.2003503


Heterotrimeric GTP-binding protein (G protein)–coupled receptors (GPCRs) are the largest family of cell surface receptors; they allow cells to respond to a wide range of endogenous and environmental signals. Class C GPCRs represent a discrete group within the GPCR family with distinct structural characteristics. Receptors belonging to this class, such as γ-aminobutyric acid type B (GABAB) receptors or metabotropic glutamate receptors (mGluRs), form constitutive dimers. However, the conformational changes within such a dimeric receptor that are associated with agonist activation are still not well understood. A study by Hlavackova et al. investigates the role of dimer formation in mGluR1 activation. Using fluorescence resonance energy transfer (FRET) approaches to assess inter- and intrasubunit conformational changes, the authors present an elegant study that sheds light on the kinetics of domain rearrangements in a class C GPCR upon ligand binding

Full text available 20 November 2012, Vol. 5, Issue 251, pe51