Therapeutic Hints from Analyzing the Attractor Landscape of the p53 Regulatory Circuit

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Sci. Signal.  29 Jan 2013:

DOI: 10.1126/scisignal.2003820


Genes are interconnected in the cell to form a genetic network that regulates cell fate. Targeting multiple genes is expected to be more effective in developing therapeutics than targeting single genes. A recent study demonstrated the possibility of systematically searching for such combinatorial treatments by characterizing the attractor landscape of the p53 regulatory circuit.

Full text available 5 February 2013, Vol. 6, Issue 261, pe5