Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States

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Sci. Signal.  12 Feb 2013:
DOI: 10.1126/scisignal.2003925


Pyruvate kinase isoform M2 (PKM2) activity is subject to complex allosteric regulation. Recently, serine and SAICAR (succinylaminoimidazolecarboxamide ribose-5′-phosphate) were identified as previously unrecognized activators of PKM2. These findings add additional complexity to how PKM2 is regulated in cells and support the notion that modulating PKM2 activity enables cells to adapt their metabolic state to specific physiological contexts.

Full article available 19 February 2013, Vol. 6, Issue 263, pe7