Sticky Signaling — Adhesion Class G Protein–Coupled Receptors Take the Stage

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Sci. Signal.  14 May 2013:
DOI: 10.1126/scisignal.2003825


Adhesion type G protein–coupled receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane spanning (7TM) receptors with unusual layout and properties. The key to understanding the function of Adhesion-GPCRs appears to be their hybrid architecture: They possess an extracellular domain (ECD) containing an extended array of protein folds fit for interactions, and structural elements of GPCRs with a 7TM and an intracellular domain (ICD). If and how these distinct protein portions interact is currently under intense investigation. Intriguingly, all Adhesion-GPCRs possess a juxtamembrane GPCR autoproteolysis-inducing (GAIN) domain that in many homologs facilitates the auto-catalytic processing into an N-terminal fragment (NTF) and a C-terminal fragment (CTF), which subsequently remain attached at the cell surface. The NTF provides the ability for combinatorial engagement with cellular or matrix-associated molecules facilitating cell adhesion, orientation, and positioning during development, immune responses, and tumor growth. The CTF, like in canonical GPCRs, initiates interactions with different types of signaling molecules including heterotrimeric G proteins, small GTPases, and transmembrane protein partners, yet the agonistic potential of most known Adhesion-GPCR ligands is uncertain. Studies with truncated receptors suggest that the NTF and CTF of Adhesion-GPCR may function as autonomous adhesive and signaling units, respectively, but other studies in nonvertebrates demonstrating NTF-CTF interplay challenge this view. Here, we discuss the available data concerning main structural elements of Adhesion-GPCRs in the context of receptor function and signaling.

Full article available 21 May 2013, Vol. 6, Issue 276, re3