Potential Pathological and Functional Links Between Long Noncoding RNAs and Hematopoiesis

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Sci. Signal.  13 Aug 2013:
DOI: 10.1126/scisignal.2004099


Differential abundance and activity of long noncoding RNAs (lncRNAs) are recognized as the hallmark features in various diseases. Here, we highlight the lncRNAs that play a functional role in the development of blood cells. Many lncRNAs and the protein complexes with which they interact have been implicated in various types of cancers. Multiple lncRNAs participate in normal and may be implicated in malignant hematopoiesis associated with blood cell cancers, such as leukemia, by regulating gene expression through such mechanisms as redirecting chromatin remodeling complexes and activating epigenetic silencing, either of which can inactivate tumor suppressor genes or activate oncogenes. Because of their potential importance in cancers of the blood, lncRNAs may be useful as diagnostic and prognostic markers and it may be possible to develop lncRNA-mediated therapy.

Full text available 20 August 2013, Vol. 6, Issue 289, re5