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Brd4 Shields Chromatin from ATM Kinase Signaling Storms

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Sci. Signal.  10 Sep 2013:
2004622
DOI: 10.1126/scisignal.2004622

Abstract

Upon activation, ataxia telangiectasia mutated (ATM) kinase rapidly phosphorylates hundreds of proteins, setting off chaotic signaling storms from areas of damaged chromatin. Recent work by Kaidi and Jackson and Floyd et al. advance our knowledge of the mechanisms that initiate or limit ATM kinase signaling storms at chromatin.

Full text available 17 September 2013, Vol. 6, Issue 293, pe30