Neurosteroid Binding Exposes a Phosphorylation Site (Model A)

This animation shows one model for how neurosteroids may increase Cl- flux through a GABA receptor. Binding of the neurosteroid (ALLO) allows a protein kinase C (PKC) phosphorylation site to be accessible. Phosphorylation of the channel increases flux through the channel. The top of the animation shows how the proteins and ligands may be interacting at the plasma membrane. The bottom of the animation shows how these interactions affect the current trace recorded using electrophysiological techniques.