Movie 2

Phosphorylation Exposes a Neurosteroid Binding Site (Model B)

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This animation shows one model for how neurosteroids may increase Cl- flux through a GABA receptor. Phosphorylation by protein kinase C (PKC) allows the neurosteroid (ALLO) to bind and increase flux through the channel. The top of the animation shows how the proteins and ligands may be interacting at the plasma membrane. The bottom of the animation shows how these interactions affect the current trace recorded using electrophysiological techniques.