The Jak-STAT Pathway Stimulated by Interferon α and Interferon β

This animation was created by Carin Cain for Curt M. Horvath and shows activation of the Jak-STAT pathway, specifically STAT1, in response to type I interferons, such as interferon α and interferon β. The animation shows that the phosphorylated STAT1 and STAT2 dimer interacts with a third transcriptional regulator IRF9 to stimulate gene expression.

D. Aaronson, C. M. Horvath, Type I Interferon α/β Pathway. (Connections Maps, as seen May 2002), [Canonical Pathway]

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